Some of the most interesting, yet often limited clinical evidence comes from so called case studies. A case study offers a unique and thorough view of the disease in question, especially of how it affects one specific individual. Although intriguing, a case study can’t be considered reliable proof for forming or changing clinical guidelines or practices, due to its lack of statistical significance, or statistics in general. You see, big clinical studies, for example, are designed to predict how the majority would react to a certain drug, leaving the rare ones marginalized. Case studies, on the other hand, are meant exactly for the ones that “don’t fit in”, but also for the ones that are simply so rare it’s impossible to draw statistically supported conclusions. It’s the rare ones that bring case studies to the spotlight, and they make great teaching material for both professors and students.
In the previous article, we started discovering what is hidden behind the name of CRISPR-Cas9. The main idea of this series of articles is to understand the background of this technology for precise genome editing. It’s truly fascinating how one unusual feature of the bacterial genome has served as an inspiration for further discoveries and developments in biotechnology. Of course, none of this would be possible without the mutual cooperation of scientists all around the world.
Today, let us welcome another S3 alumnus to the Presenting Alumni stage – Felix Lahr, now a new biochemistry student at the University of Heidelberg. Despite having just finished high school, Felix is already shaping up to be an incredibly accomplished and inspired scientist. Join us for an overview of his endeavors so far and his experience as a participant at S3 2019.
CRISPR-Cas9 technology probably needs no special introduction. After all, exactly this system for precise genome editing has started a complete revolution of genetic engineering. Still, the focus of today’s article won’t be the application of CRISPR-Cas9 in biotechnology, no matter how fascinating it gets (but no worries, we will come back to it some other time).
Today, it’s time to take a look at the background of this almost perfect molecular tool, today’s version of which is reduced to only one enzyme and one carefully picked RNA molecule.