Some of the most interesting, yet often limited clinical evidence comes from so called case studies. A case study offers a unique and thorough view of the disease in question, especially of how it affects one specific individual. Although intriguing, a case study can’t be considered reliable proof for forming or changing clinical guidelines or practices, due to its lack of statistical significance, or statistics in general. You see, big clinical studies, for example, are designed to predict how the majority would react to a certain drug, leaving the rare ones marginalized. Case studies, on the other hand, are meant exactly for the ones that “don’t fit in”, but also for the ones that are simply so rare it’s impossible to draw statistically supported conclusions. It’s the rare ones that bring case studies to the spotlight, and they make great teaching material for both professors and students.